Ontology highlight
ABSTRACT:
SUBMITTER: Maness NJ
PROVIDER: S-EPMC2953171 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Maness Nicholas J NJ Walsh Andrew D AD Piaskowski Shari M SM Furlott Jessica J Kolar Holly L HL Bean Alexander T AT Wilson Nancy A NA Watkins David I DI
Journal of virology 20100825 21
Vaccines designed to elicit AIDS virus-specific CD8+ T cells should engender broad responses. Emerging data indicate that alternate reading frames (ARFs) of both human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) encode CD8+ T cell epitopes, termed cryptic epitopes. Here, we show that SIV-specific CD8+ T cells from SIV-infected rhesus macaques target 14 epitopes in eight ARFs during SIV infection. Animals recognized up to five epitopes, totaling nearly one-quarter of the ...[more]