A selenide-based approach to photochemical cleavage of peptide and protein backbones at engineered backbone esters.
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ABSTRACT:
SUBMITTER: Eastwood AL
PROVIDER: S-EPMC2953381 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Publications
A selenide-based approach to photochemical cleavage of peptide and protein backbones at engineered backbone esters.
Eastwood Amy L AL Blum Angela P AP Zacharias Niki M NM Dougherty Dennis A DA
The Journal of organic chemistry 20091201 23
A strategy for photochemical cleavage of peptide and protein backbones is described, which is based on a selenide-mediated cleavage of a backbone ester moiety. Studies in model systems establish the viability of the chemistry and suggest the method could be a valuable tool for chemical biology studies of proteins. ...[more]
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