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Photochemical cleavage of leader peptides.

ABSTRACT: We report a photolabile linker compatible with Fmoc solid phase peptide synthesis and Cu(I)-catalyzed alkyne-azide cycloaddition that allows photochemical cleavage to afford a C-terminal peptide fragment with a native amino terminus.

SUBMITTER: Bindman N

PROVIDER: S-EPMC3100556 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature

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Photochemical cleavage of leader peptides.

Bindman Noah N Merkx Remco R Koehler Robert R Herrman Nicholas N van der Donk Wilfred A WA

Chemical communications (Cambridge, England) 20101102 47

We report a photolabile linker compatible with Fmoc solid phase peptide synthesis and Cu(I)-catalyzed alkyne-azide cycloaddition that allows photochemical cleavage to afford a C-terminal peptide fragment with a native amino terminus. ...[more]

PMID: 21046030

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