Ontology highlight
ABSTRACT:
SUBMITTER: Kawahara Y
PROVIDER: S-EPMC2953418 | biostudies-literature | 2007 Feb
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20070201 5815
Primary transcripts of certain microRNA (miRNA) genes are subject to RNA editing that converts adenosine to inosine. However, the importance of miRNA editing remains largely undetermined. Here we report that tissue-specific adenosine-to-inosine editing of miR-376 cluster transcripts leads to predominant expression of edited miR-376 isoform RNAs. One highly edited site is positioned in the middle of the 5'-proximal half "seed" region critical for the hybridization of miRNAs to targets. We provide ...[more]