Ontology highlight
ABSTRACT:
SUBMITTER: Kajita M
PROVIDER: S-EPMC2954245 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Kajita Mihoko M Hogan Catherine C Harris Andrew R AR Dupre-Crochet Sophie S Itasaki Nobue N Kawakami Koichi K Charras Guillaume G Tada Masazumi M Fujita Yasuyuki Y
Journal of cell science 20091221 Pt 2
At the initial stage of carcinogenesis, transformation occurs in a single cell within an epithelial sheet. However, it remains unknown what happens at the boundary between normal and transformed cells. Using Madin-Darby canine kidney (MDCK) cells transformed with temperature-sensitive v-Src, we have examined the interface between normal and Src-transformed epithelial cells. We show that Src-transformed cells are apically extruded when surrounded by normal cells, but not when Src cells alone are ...[more]