Ontology highlight
ABSTRACT:
SUBMITTER: Anton KA
PROVIDER: S-EPMC6224566 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Anton Katarzyna A KA Kajita Mihoko M Narumi Rika R Fujita Yasuyuki Y Tada Masazumi M
Nature communications 20181108 1
At the initial stage of carcinogenesis single mutated cells appear within an epithelium. Mammalian in vitro experiments show that potentially cancerous cells undergo live apical extrusion from normal monolayers. However, the mechanism underlying this process in vivo remains poorly understood. Mosaic expression of the oncogene vSrc in a simple epithelium of the early zebrafish embryo results in extrusion of transformed cells. Here we find that during extrusion components of the cytokinetic ring a ...[more]