Ontology highlight
ABSTRACT:
SUBMITTER: Burks SR
PROVIDER: S-EPMC2954609 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
The Journal of organic chemistry 20101001 19
Electron paramagnetic resonance imaging (EPRI) using nitroxides is an emergent imaging method for studying in vivo physiology, including O(2) distribution in various tissues. Such imaging capabilities would allow O(2) mapping in tumors and in different brain regions following hypoxia or drug abuse. We have recently demonstrated that the anion of 3-carboxy-2,2,5,5-tetramethyl-1-pyrrolidinyloxyl (2) can be entrapped in brain tissue to quantitate O(2) concentration in vivo. To increase the sensitiv ...[more]