Ontology highlight
ABSTRACT:
SUBMITTER: Sanzhaeva U
PROVIDER: S-EPMC6327950 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Sanzhaeva Urikhan U Xu Xuan X Guggilapu Priyaankadevi P Tseytlin Mark M Khramtsov Valery V VV Driesschaert Benoit B
Angewandte Chemie (International ed. in English) 20180807 36
Enzyme activities are well established biomarkers of many pathologies. Imaging enzyme activity directly in vivo may help to gain insight into the pathogenesis of various diseases but remains extremely challenging. In this communication, we report the use of EPR imaging (EPRI) in combination with a specially designed paramagnetic enzymatic substrate to map alkaline phosphatase activity with a high selectivity, thereby demonstrating the potential of EPRI to map enzyme activity. ...[more]