Dataset Information

Asthma susceptible genes in Chinese population: a meta-analysis.

ABSTRACT:

Background

Published data regarding the associations between genetic variants and asthma risk in Chinese population were inconclusive. The aim of this study was to investigate asthma susceptible genes in Chinese population.

Methods

The authors conducted 18 meta-analyzes for 18 polymorphisms in 13 genes from eighty-two publications.

Results

Seven polymorphisms were found being associated with risk of asthma, namely: A Disintegrin and Metalloprotease 33 (ADAM33) T1-C/T (odds ratio [OR] = 6.07, 95% confidence interval [CI]: 2.69-13.73), Angiotensin-Converting Enzyme (ACE) D/I (OR = 3.85, 95%CI: 2.49-5.94), High-affinity IgE receptor ? chain (Fc?RI?) -6843G/A (OR = 1.49, 95%CI: 1.01-2.22), Interleukin 13(IL-13) -1923C/T (OR = 2.99, 95%CI: 2.12-4.24), IL-13 -2044A/G (OR = 1.49, 95%CI: 1.07-2.08), Regulated upon Activation, Normal T cell Expressed and Secreted (RANTES) -28C/G (OR = 1.64, 95%CI: 1.09-2.46), Tumor Necrosis Factor-? (TNF-?) -308G/A(OR = 1.42, 95%CI: 1.09, 1.85). After subgroup analysis by age, the ACE D/I, ?2-Adrenergic Receptor (?2-AR) -79G/C, TNF-? -308G/A, Interleukin 4 receptor(IL-4R) -1902G/A and IL-13 -1923C/T polymorphisms were found significantly associated with asthma risk in Chinese children. In addition, the ACE D/I, Fc?RI? -6843G/A, TNF-? -308G/A, IL-13 -1923C/T and IL-13 -2044A/G polymorphisms were associated with asthma risk in Chinese adults.

Conclusion

ADAM33, Fc?RI?, RANTES, TNF-?, ACE, ?2-AR, IL-4R and IL-13 genes could be proposed as asthma susceptible genes in Chinese population. Given the limited number of studies, more data are required to validate these associations.

SUBMITTER: Li X

PROVIDER: S-EPMC2955661 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature

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Publications

Asthma susceptible genes in Chinese population: a meta-analysis.

Li Xiaobo X Zhang Yonggang Y Zhang Jie J Xiao Yuling Y Huang Jin J Tian Can C He Chao C Deng Yao Y Yang Yingying Y Fan Hong H

Respiratory research 20100924

<h4>Background</h4>Published data regarding the associations between genetic variants and asthma risk in Chinese population were inconclusive. The aim of this study was to investigate asthma susceptible genes in Chinese population.<h4>Methods</h4>The authors conducted 18 meta-analyzes for 18 polymorphisms in 13 genes from eighty-two publications.<h4>Results</h4>Seven polymorphisms were found being associated with risk of asthma, namely: A Disintegrin and Metalloprotease 33 (ADAM33) T1-C/T (odds ...[more]

PMID: 20868478

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Dataset Information

Asthma susceptible genes in Chinese population: a meta-analysis.

Background

Methods

Results

Conclusion

Publications

Asthma susceptible genes in Chinese population: a meta-analysis.

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