Ontology highlight
ABSTRACT:
SUBMITTER: Lidonnici MR
PROVIDER: S-EPMC2955805 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Lidonnici Maria Rosa MR Audia Alessandra A Soliera Angela Rachele AR Prisco Marco M Ferrari-Amorotti Giovanna G Waldron Todd T Donato Nick N Zhang Ying Y Martinez Robert V RV Holyoake Tessa L TL Calabretta Bruno B
Cancer research 20101005 20
Ectopic expression of CAAT/enhancer binding protein α (C/EBPα) in p210BCR/ABL-expressing cells induces granulocytic differentiation, inhibits proliferation, and suppresses leukemogenesis. To dissect the molecular mechanisms underlying these biological effects, C/EBPα-regulated genes were identified by microarray analysis in 32D-p210BCR/ABL cells. One of the genes whose expression was activated by C/EBPα in a DNA binding-dependent manner in BCR/ABL-expressing cells is the transcriptional represso ...[more]