Ontology highlight
ABSTRACT:
SUBMITTER: Duan Z
PROVIDER: S-EPMC156304 | biostudies-literature | 2003 May
REPOSITORIES: biostudies-literature
Duan Zhijun Z Horwitz Marshall M
Proceedings of the National Academy of Sciences of the United States of America 20030429 10
Gfi-1 is a zinc finger transcriptional repressor originally recognized for its role in T cell differentiation and lymphomas. Recent experiments reveal that gene-targeted Gfi-1-deficient mice are neutropenic and that Gfi-1 mutations cause human neutropenia. In both cases, myeloid progenitor cells lose the ability to distinctly differentiate granulocytes from monocytes. The molecular mechanism of the hematopoietic abnormalities caused by Gfi-1 deficiency remains undetermined because of a lack of k ...[more]