Ontology highlight
ABSTRACT:
SUBMITTER: Lee JJ
PROVIDER: S-EPMC2955808 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Lee Jessica J JJ Essers Jonah B JB Kugathasan Subra S Escher Johanna C JC Lettre Guillaume G Butler Johannah L JL Stephens Michael C MC Ramoni Marco F MF Grand Richard J RJ Hirschhorn Joel J
Annals of human genetics 20100915 6
The etiology of growth impairment in Crohn's disease (CD) has been inadequately explained by nutritional, hormonal, and/or disease-related factors, suggesting that genetics may be an additional contributor. The aim of this cross-sectional study was to investigate genetic variants associated with linear growth in pediatric-onset CD. We genotyped 951 subjects (317 CD patient-parent trios) for 64 polymorphisms within 14 CD-susceptibility and 23 stature-associated loci. Patient height-for-age Z-scor ...[more]