Ontology highlight
ABSTRACT:
SUBMITTER: Treiber N
PROVIDER: S-EPMC2956205 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Treiber Nora N Treiber Thomas T Zocher Georg G Grosschedl Rudolf R
Genes & development 20100928 20
Early B-cell factor 1 (Ebf1) is a key transcriptional determinant of B-lymphocyte differentiation whose DNA-binding domain has no sequence similarity to other transcription factor families. Here we report the crystal structure of an Ebf1 dimer bound to its palindromic recognition site. The DNA-binding domain adopts a pseudoimmunoglobulin-like fold with novel topology, but is structurally similar to the Rel homology domains of NFAT and NF-κB. Ebf1 contacts the DNA with two loop-based modules and ...[more]