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BST-2/tetherin: a new component of the innate immune response to enveloped viruses.

ABSTRACT: The interferon-inducible, transmembrane protein BST-2 (CD317, tetherin) directly holds fully formed enveloped virus particles to the cells that produce them, inhibiting their spread. BST-2 inhibits members of the retrovirus, filovirus, arenavirus and herpesvirus families. These viruses encode a variety of proteins to degrade BST-2 and/or direct it away from its site of action at the cell surface. Viral antagonism has subjected BST-2 to positive selection, leading to species-specific differences that presented a barrier to the transmission of simian immunodeficiency viruses (SIVs) to humans. This barrier was crossed by HIV-1 when its Vpu protein acquired activity as a BST-2 antagonist. Here, we review this new host-pathogen relationship and discuss its impact on the evolution of primate lentiviruses and the origins of the HIV pandemic.

SUBMITTER: Evans DT

PROVIDER: S-EPMC2956607 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature

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BST-2/tetherin: a new component of the innate immune response to enveloped viruses.

Evans David T DT Serra-Moreno Ruth R Singh Rajendra K RK Guatelli John C JC

Trends in microbiology 20100803 9

The interferon-inducible, transmembrane protein BST-2 (CD317, tetherin) directly holds fully formed enveloped virus particles to the cells that produce them, inhibiting their spread. BST-2 inhibits members of the retrovirus, filovirus, arenavirus and herpesvirus families. These viruses encode a variety of proteins to degrade BST-2 and/or direct it away from its site of action at the cell surface. Viral antagonism has subjected BST-2 to positive selection, leading to species-specific differences ...[more]

PMID: 20688520

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