Biological synthesis of tooth enamel instructed by an artificial matrix.
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ABSTRACT:
SUBMITTER: Huang Z
PROVIDER: S-EPMC2956865 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Publications
Biological synthesis of tooth enamel instructed by an artificial matrix.
Huang Zhan Z Newcomb Christina J CJ Bringas Pablo P Stupp Samuel I SI Snead Malcolm L ML
Biomaterials 20100924 35
The regenerative capability of enamel, the hardest tissue in the vertebrate body, is fundamentally limited due to cell apoptosis following maturation of the tissue. Synthetic strategies to promote enamel formation have the potential to repair damage, increase the longevity of teeth and improve the understanding of the events leading to tissue formation. Using a self-assembling bioactive matrix, we demonstrate the ability to induce ectopic formation of enamel at chosen sites adjacent to a mouse i ...[more]
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