Ontology highlight
ABSTRACT:
SUBMITTER: Inaba K
PROVIDER: S-EPMC2957217 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Inaba Kenji K Masui Shoji S Iida Hiroka H Vavassori Stefano S Sitia Roberto R Suzuki Mamoru M
The EMBO journal 20100910 19
In the endoplasmic reticulum (ER) of eukaryotic cells, Ero1 flavoenzymes promote oxidative protein folding through protein disulphide isomerase (PDI), generating reactive oxygen species (hydrogen peroxide) as byproducts. Therefore, Ero1 activity must be strictly regulated to avoid futile oxidation cycles in the ER. Although regulatory mechanisms restraining Ero1α activity ensure that not all PDIs are oxidized, its specificity towards PDI could allow other resident oxidoreductases to remain reduc ...[more]