Ontology highlight
ABSTRACT:
SUBMITTER: Anvret A
PROVIDER: S-EPMC2957232 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Anvret Anna A Ran Caroline C Westerlund Marie M Thelander Ann-Christin AC Sydow Olof O Lind Charlotta C Håkansson Anna A Nissbrandt Hans H Galter Dagmar D Belin Andrea Carmine AC
Parkinson's disease 20100614
Genes important for mitochondrial function have been implicated in Parkinson's disease (PD). Mitochondrial translation initiation factor 3 (MTIF3) is a nuclear encoded protein required for the initiation of complex formation on mitochondrial ribosomes. Dysfunction of MTIF3 may impair mitochondrial function and dopamine neurons appear to be particularly vulnerable to oxidative stress, which may relate to their degeneration in PD. An association was recently reported between the synonymous rs7669( ...[more]