Ontology highlight
ABSTRACT:
SUBMITTER: Machrouhi F
PROVIDER: S-EPMC2957560 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Machrouhi Fouzia F Ouhamou Nouara N Laderoute Keith K Calaoagan Joy J Bukhtiyarova Marina M Ehrlich Paula J PJ Klon Anthony E AE
Bioorganic & medicinal chemistry letters 20100919 22
We have designed and synthesized analogues of compound C, a non-specific inhibitor of 5'-AMP-activated protein kinase (AMPK), using a computational fragment-based drug design (FBDD) approach. Synthesizing only twenty-seven analogues yielded a compound that was equipotent to compound C in the inhibition of the human AMPK (hAMPK) α2 subunit in the heterotrimeric complex in vitro, exhibited significantly improved selectivity against a subset of relevant kinases, and demonstrated enhanced cellular i ...[more]