Ontology highlight
ABSTRACT:
SUBMITTER: Brockway AJ
PROVIDER: S-EPMC4966539 | biostudies-other | 2016 Jul
REPOSITORIES: biostudies-other
Synthesis 20160701 13
An improved synthesis of MDL 73811 - a potent AdoMetDC (S-adenosylmethionine decarboxylease) inhibitor and anti-trypanosomal compound with in vivo activity has been completed in four steps from commercially available 2',3'-<i>O</i>-isopropylideneadenosine. Utilization of Mitsunobu chemistry was crucial for the reliable and scalable introduction of the 5'-methylamine moiety, which was problematic using traditional activation/displacement chemistry as previously reported. All reactions in this syn ...[more]