Ontology highlight
ABSTRACT:
SUBMITTER: Zhao H
PROVIDER: S-EPMC2957563 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Bioorganic & medicinal chemistry letters 20100916 22
The discovery of 3-deazathiamine diphosphate (deazaThDP) as a potent inhibitor analog of the cofactor thiamine diphosphate (ThDP) has highlighted the need for an efficient and scalable synthesis of deazaThDP. Such a method would facilitate development of analogs with the ability to inhibit individual ThDP-dependent enzymes selectively. Toward the goal of developing selective inhibitors of the mycobacterial enzyme 2-hydroxy-3-oxoadipate synthase (HOAS), we report an improved synthesis of deazaThD ...[more]