Ontology highlight
ABSTRACT:
SUBMITTER: Correa D
PROVIDER: S-EPMC2958174 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Developmental cell 20101001 4
In the growth plate, the interplay between parathyroid hormone-related peptide (PTHrP) and Indian hedgehog (Ihh) signaling tightly regulates chondrocyte proliferation and differentiation during longitudinal bone growth. We found that PTHrP increases the expression of Zfp521, a zinc finger transcriptional coregulator, in prehypertrophic chondrocytes. Mice with chondrocyte-targeted deletion of Zfp521 resembled PTHrP(-/-) and chondrocyte-specific PTHR1(-/-) mice, with decreased chondrocyte prolifer ...[more]