The Relationship between the Transforming Growth Factor ?1 T29C Gene Polymorphism and Left Ventricular Geometry and Function in Hypertensive Subjects.

ABSTRACT: The distribution of the T29C TGF?1 gene polymorphism was analyzed in 198 hypertensives with left ventricular hypertrophy (LVH) and in 235 hypertensives without LVH. Circulating TGF?1 levels, procollagen type III levels, microalbuminuria, and left ventricular geometry and function were evaluated in all the hypertensives with LVH subgrouped according to T29C TGF?1 gene polymorphism. Circulating TGF?1 was evaluated by ELISA technique, procollagen type III by a specific radioimmunoassay, microalbuminuria by radioimmunoassay, and left ventricular geometry and function by echocardiography. All groups were comparable for gender, age, and sex. Regarding T29C TGF?1 gene polymorphism, prevalence of TC or CC genotypes was significantly (P < .05) higher in hypertensives with LVH than hypertensives without LVH TC and CC LVH hypertensives were characterized by a higher prevalence of subjects with microalbuminuria (P < .05 TC and CC versus TT), by increased levels of TGF?1, procollagen type III, urinary albumin excretion, LVM, LVM/h(2.7), and lower values of left ventricular ejection fraction (P < .05 TC and CC versus TT). Our data suggest that T29C TGF?1 gene polymorphism was associated with clinical characteristics adequate to recognize a subset of LVH hypertensives with a higher severity of hypertension.

SUBMITTER: Scaglione R 

PROVIDER: S-EPMC2958444 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature