Pharmacogenomics of mood stabilizers in the treatment of bipolar disorder.
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ABSTRACT:
SUBMITTER: Squassina A
PROVIDER: S-EPMC2958627 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
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Pharmacogenomics of mood stabilizers in the treatment of bipolar disorder.
Squassina Alessio A Manchia Mirko M Del Zompo Maria M
Human genomics and proteomics : HGP 20100803
Bipolar disorder (BD) is a chronic and often severe psychiatric illness characterized by manic and depressive episodes. Among the most effective treatments, mood stabilizers represent the keystone in acute mania, depression, and maintenance treatment of BD. However, treatment response is a highly heterogeneous trait, thus emphasizing the need for a structured informational framework of phenotypic and genetic predictors. In this paper, we present the current state of pharmacogenomic research on l ...[more]
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