Ontology highlight
ABSTRACT:
SUBMITTER: Caudron F
PROVIDER: S-EPMC2958848 | biostudies-literature | 2010
REPOSITORIES: biostudies-literature
Caudron Fabrice F Denarier Eric E Thibout-Quintana Jenny-Constanza JC Brocard Jacques J Andrieux Annie A Fourest-Lieuvin Anne A
PloS one 20101021 10
Ser172 of β tubulin is an important residue that is mutated in a human brain disease and phosphorylated by the cyclin-dependent kinase Cdk1 in mammalian cells. To examine the role of this residue, we used the yeast S. cerevisiae as a model and produced two different mutations (S172A and S172E) of the conserved Ser172 in the yeast β tubulin Tub2p. The two mutants showed impaired cell growth on benomyl-containing medium and at cold temperatures, altered microtubule (MT) dynamics, and altered nucle ...[more]