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6?-Acetamido-5?-hydroxy-cholestan-3?-yl acetate.

ABSTRACT: The title steroid, C(31)H(53)NO(4), was prepared from the corresponding 5?,6?-epoxy-cholestane. The conformation of the six-membered rings is close to a chair form, while the five-membered ring adopts a twist conformation. The hydroxyl and acetamide groups are in axial positions. The nucleophilic species bound to the steroid nucleus at position 6 by the ?-face, whereas the hydroxyl group at position 5 has ?-orientation. All rings are trans-fused. The crystal packing shows that the mol-ecules related by twofold symmetry exist as O-H?O hydrogen-bonded dimers.

SUBMITTER: Pinto RM

PROVIDER: S-EPMC2959794 | biostudies-literature |

REPOSITORIES: biostudies-literature

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