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(3R,4R,5S)-4-(4-Methyl-phen-yl)-2,3-diphenyl-7-[(R)-1-phenyl-ethyl]-1-oxa-2,7-diaza-spiro-[4.5]decan-10-one oxime.

ABSTRACT: In the title compound, C(34)H(35)N(3)O(2), the polysubstituted piperidine ring adopts a chair conformation and the isoxazolidine ring is in an envelope form. The mol-ecules are linked into a chain along the b axis by O-H?N, C-H?O and C-H?N inter-actions. The chains are cross-linked via weak C-H?? inter-actions.

SUBMITTER: Begum GC

PROVIDER: S-EPMC2960745 | biostudies-literature | 2008 Feb

REPOSITORIES: biostudies-literature

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(3R,4R,5S)-4-(4-Methyl-phen-yl)-2,3-diphenyl-7-[(R)-1-phenyl-ethyl]-1-oxa-2,7-diaza-spiro-[4.5]decan-10-one oxime.

Begum G Chanthini GC Kumar R Suresh RS Suresh J J Gopinathan C C Lakshman P L Nilantha PL

Acta crystallographica. Section E, Structure reports online 20080215 Pt 3

In the title compound, C(34)H(35)N(3)O(2), the polysubstituted piperidine ring adopts a chair conformation and the isoxazolidine ring is in an envelope form. The mol-ecules are linked into a chain along the b axis by O-H⋯N, C-H⋯O and C-H⋯N inter-actions. The chains are cross-linked via weak C-H⋯π inter-actions. ...[more]

PMID: 21201928

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(1R,4R,5R)-1,3,4-Triphenyl-7-[(R)-1-phenyl-ethyl]-2-oxa-3,7-diaza-spiro-[4.5]decan-10-one.

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Project description:The title compound, C(22)H(25)F(5)N(4)O(9), is a stable penta-fluoro-phenyl ester inter-mediate in the synthesis of novel homo-oligomeric structures containing branched carbon chains. The structure is epimeric to the previously characterized dimeric penta-fluoro-phenyl ester with stereochemistry (3R,4R,5R), which was synthesized using d-ribose as starting material. The crystal structure of the title mol-ecule removes any ambiguities arising from the relative stereochemistries of the six chiral centres. Two hydrogen bonds, bifurcating from the NH group, stabilize the crystal: one intra-molecular and one inter-molecular, both involving O atoms of the meth-oxy groups. The asymmetric unit contains two independent mol-ecules not related by any pseudo-symmetry operators. The major conformational differences are localized, leading to one mol-ecule being extended compared to the other. The collected crystal was twinned (twin ratio is 0.939:0.061), and the azide group is positionally disordered over two positions in one mol-ecule [occupancy ratio 0.511?(18):0.489?(18)].

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(3R*,4R*,5S*)-4-(4-Methyl-phen-yl)-2,3-diphenyl-7-[(R*)-1-phenyl-ethyl]-1-oxa-2,7-diaza-spiro-[4.5]decan-10-one oxime.

Publications

(3R*,4R*,5S*)-4-(4-Methyl-phen-yl)-2,3-diphenyl-7-[(R*)-1-phenyl-ethyl]-1-oxa-2,7-diaza-spiro-[4.5]decan-10-one oxime.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

(3R,4R,5S)-4-(4-Methyl-phen-yl)-2,3-diphenyl-7-[(R)-1-phenyl-ethyl]-1-oxa-2,7-diaza-spiro-[4.5]decan-10-one oxime.

(3R,4R,5S)-4-(4-Methyl-phen-yl)-2,3-diphenyl-7-[(R)-1-phenyl-ethyl]-1-oxa-2,7-diaza-spiro-[4.5]decan-10-one oxime.