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6,6,9a-Trimethyl-5,5a,6,7,8,9,9a,9b-octa-hydro-naphtho[1,2-c]furan-1(3H)-one.

ABSTRACT: In the crystal structure of the title compound, C(15)H(22)O(2), the cyclo-hexene and cyclo-hexane rings adopt half-boat and chair conformations, respectively, and the lactone ring is in an envelope conformation.

SUBMITTER: Brito I

PROVIDER: S-EPMC2960948 | biostudies-literature |

REPOSITORIES: biostudies-literature

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3,5a,9-Trimethyl-8-(2-phenylhydrazin-1-ylidene)-4,5,5a,9b-tetrahydro-3aH,8H-naphtho[1,2-b]furan-2(3H)-one.

Project description:The title compound, C(21)H(24)N(2)O(2), is a phenyl hydrazine derivative of the well known anthelminthic agent α-santonin, which is composed of three fused rings (benzodieneone, cyclo-hexane and γ-lactone). The cyclo-hexa-dienone ring adopts a boat conformation, the cyclo-hexane ring is in a chair conformation and the trans-fused γ-lactone ring adopts a C-envelope conformation. In the crystal, mol-ecules are linked by N-H⋯O and C-H⋯O hydrogen bonds, forming chains along the a axis.

| S-EPMC3393924 | biostudies-literature

8-[(2-Hy-droxy-phen-yl)imino]-3,5a,9-trimethyl-3a,4,5,5a,8,9b-hexa-hydro-naphtho-[1,2-b]furan-2(3H)-one.

Project description:The title compound, C(21)H(23)NO(3), is a phenyl-imine derivative of the well known anthelmintic agent α-santonin. The trans-fused cyclo-hexane and γ-lactone rings of the α-santonin ring system adopt chair and envelope conformations, respectively, whereas the hexa-diene ring is approximately planar [maximum deviation = 0.029 (4) Å] and forms a dihedral angle of 62.30 (11)° with the benzene ring. An intra-molecular O-H⋯N hydrogen bond is observed.

| S-EPMC3393965 | biostudies-literature

6,8-Dihy-droxy-8a-methyl-3,5-dimethyl-idenedeca-hydro-naphtho-[2,3-b]furan-2(3H)-one.

Project description:The title compound, C(15)H(20)O(4), is a eudesmanolide isolated from the Chinese medicinal plant Carpesium tris-te Maxim. The mol-ecule contains three rings, viz. two fused six-membered rings in chair conformations and a five-membered ring in a flattened envelope conformation. In the crystal, two hy-droxy groups are involved in the formation of intra- and inter-molecular O-H?O hydrogen bonds. The H atoms in these groups are split, with site-occupation factors of 0.5. The inter-molecular hydrogen bonds link mol-ecules into chains propagating in [010].

| S-EPMC3515328 | biostudies-literature

3-Hydr-oxy-3a,6,8c-trimethyl-perhydro-oxireno[2',3':7,8]naphtho[1,2-b]furan-7(2H)-one.

Project description:The title compound, C(15)H(22)O(4), consists of two trans-fused six-membered rings and a trans-fused five-membered ?-lactone. The ep-oxy and hydroxyl groups are ?-oriented. The cyclo-hexane rings adopt half-chair and chair conformations and the lactone ring is in an envelope conformation. The mol-ecular structure is stabilized by one O-H?O and three C-H?O intra-molecular hydrogen bonds.

| S-EPMC2977239 | biostudies-literature

9?-Hy-droxy-6,9-dimethyl-3-methyl-ene-3a,4,8,9,9a,9b-hexa-hydro-azuleno[4,5-b]furan-2(3H)-one.

Project description:The title compound, C(15)H(18)O(3), was synthesized from 9?-hy-droxy-parthenolide (9?-hy-droxy-4,8-dimethyl-12-methylen-3,14-dioxa-tricyclo-[9.3.0.0(2,4)]tetra-dec-7-en-13-one), which was isolated from the chloro-form extract of the aerial parts of Anvillea radiata. The seven-membered ring of the title compound shows a chair conformation, while the five-membered rings exibit different conformations, viz a twisted one for the lactone ring and an envelope conformation for the other five-membered ring with the C atom closest to the hydroxy group forming the flap. In the crystal, O-H?O hydrogen bonds connect mol-ecules into dimers that are inter-connected by C-H?O inter-actions, producing supramolecular chains along the b axis.

| S-EPMC3275063 | biostudies-literature

5,9-Dihy-droxy-9-methyl-3,6-dimethyl-ene-3a,4,5,6,6a,7,8,9,9a,9b-deca-hydro-azuleno[4,5-b]furan-2(3H)-one.

Project description:The title compound, C(15)H(20)O(4), was synthesized from 9?-hy-droxy-parthenolide (9?-hy-droxy-4,8-dimethyl-12-methyl-ene-3,14-dioxatricyclo-[9.3.0.0(2,4)]tetra-dec-7-en-13-one), which was isolated from the chloro-form extract of the aerial parts of Anvillea radiata. The seven-membered ring has a chair conformation, while the five-membered rings display twisted conformations. The dihedral angle between the seven-membered ring and the lactone ring is 21.69?(10)°. In the crystal, mol-ecules are linked into chains propagating along the c axis by inter-molecular O-H?O hydrogen bonds; an intra-molecular O-H?O link also occurs.

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7-[2-(3-Fur-yl)eth-yl]-7,8-dimethyl-3,5,6,6a,7,8,9,10-octa-hydro-1H-naphtho-[1,8a-c]furan-3-one.

Project description:In the title mol-ecule, C(20)H(26)O(3), a clerodane diterpenoid isolated from Dodonaea viscosa-, the trans-fused six-membered rings of the deca-line system display chair conformations. The five-membered lactone ring adopts an envelope conformation and the five-membered furan ring is essentially planar with a maximum deviation of 0.0052 (12) Å.

| S-EPMC2983354 | biostudies-literature

2-Bromo-1,6,6-trimethyl-6,7,8,9-tetra-hydro-phenanthro[1,2-b]furan-10,11-dione.

Project description:In the title compound, C19H17BrO3, the ring skeleton is located on a crystallographic mirror plane; two C atoms of the cyclo-hexene ring are disordered over the two locations to satisfy the preferred ring conformation. In the crystal, C-H⋯O hydrogen bonds link the mol-ecules into chains along the a axis. π-π stacking inter-actions between benzo-quinone rings, with a centroid-centroid distance of 3.7225 (4) Å, are also observed, which connect the chains into a two-dimensional networkparallel to the ab plane.

| S-EPMC3684922 | biostudies-literature

9-[(Furan-2-ylmeth-yl)amino]-5-(3,4,5-trimeth-oxy-phen-yl)-5,5a,8a,9-tetra-hydro-furo[3',4':6,7]naphtho-[2,3-d][1,3]dioxol-6(8H)-one.

Project description:In title compound, C(27)H(27)NO(8), the dihydrofuran-2(3H)-one ring and the six-membered ring fused to it both display envelope conformations. The dihedral angle between the benzene ring of the benzo[d][1,3]dioxole group and the other benzene ring is 60.59?(2)°. In the crystal, weak inter-molecular C-H?O hydrogen bonds link the mol-ecules into a three-dimensional network. The furan ring is disordered over two sets of sites with occupancies of 0.722?(7) and 0.278?(7).

| S-EPMC3213528 | biostudies-literature

7-Iodo-3,3-diphenyl-octa-hydro-benzo-furan.

Project description:The title compound, C20H21IO, was synthesized by cyclo-haloetherification of 2-(cyclo-hex-2-en-yl)-2,2-diphenyl-ethanol in CH2Cl2, and crystallized with two independent mol-ecules in the asymmetric unit. The six-membered cyclo-hexane ring adopts a chair conformation, while the five-membered ring adopts an envelope conformation with the fused C atom opposite the O atom as the flap in each case [displacements of the flap atoms = 0.6813 (3) and 0.6679 (3) Å]. In the crystal, mol-ecules are linked via pairs of C-H⋯π inter-actions, forming inversion dimers.

| S-EPMC3629630 | biostudies-literature

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