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8-[(2-Hy-droxy-phen-yl)imino]-3,5a,9-trimethyl-3a,4,5,5a,8,9b-hexa-hydro-naphtho-[1,2-b]furan-2(3H)-one.

ABSTRACT: The title compound, C(21)H(23)NO(3), is a phenyl-imine derivative of the well known anthelmintic agent α-santonin. The trans-fused cyclo-hexane and γ-lactone rings of the α-santonin ring system adopt chair and envelope conformations, respectively, whereas the hexa-diene ring is approximately planar [maximum deviation = 0.029 (4) Å] and forms a dihedral angle of 62.30 (11)° with the benzene ring. An intra-molecular O-H⋯N hydrogen bond is observed.

SUBMITTER: Yousuf S

PROVIDER: S-EPMC3393965 | biostudies-literature |

REPOSITORIES: biostudies-literature

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6,6,9a-Trimethyl-5,5a,6,7,8,9,9a,9b-octa-hydro-naphtho[1,2-c]furan-1(3H)-one.

Project description:In the crystal structure of the title compound, C(15)H(22)O(2), the cyclo-hexene and cyclo-hexane rings adopt half-boat and chair conformations, respectively, and the lactone ring is in an envelope conformation.

| S-EPMC2960948 | biostudies-literature

3,5a,9-Trimethyl-8-(2-phenylhydrazin-1-ylidene)-4,5,5a,9b-tetrahydro-3aH,8H-naphtho[1,2-b]furan-2(3H)-one.

Project description:The title compound, C(21)H(24)N(2)O(2), is a phenyl hydrazine derivative of the well known anthelminthic agent α-santonin, which is composed of three fused rings (benzodieneone, cyclo-hexane and γ-lactone). The cyclo-hexa-dienone ring adopts a boat conformation, the cyclo-hexane ring is in a chair conformation and the trans-fused γ-lactone ring adopts a C-envelope conformation. In the crystal, mol-ecules are linked by N-H⋯O and C-H⋯O hydrogen bonds, forming chains along the a axis.

| S-EPMC3393924 | biostudies-literature

9?-Hy-droxy-6,9-dimethyl-3-methyl-ene-3a,4,8,9,9a,9b-hexa-hydro-azuleno[4,5-b]furan-2(3H)-one.

Project description:The title compound, C(15)H(18)O(3), was synthesized from 9?-hy-droxy-parthenolide (9?-hy-droxy-4,8-dimethyl-12-methylen-3,14-dioxa-tricyclo-[9.3.0.0(2,4)]tetra-dec-7-en-13-one), which was isolated from the chloro-form extract of the aerial parts of Anvillea radiata. The seven-membered ring of the title compound shows a chair conformation, while the five-membered rings exibit different conformations, viz a twisted one for the lactone ring and an envelope conformation for the other five-membered ring with the C atom closest to the hydroxy group forming the flap. In the crystal, O-H?O hydrogen bonds connect mol-ecules into dimers that are inter-connected by C-H?O inter-actions, producing supramolecular chains along the b axis.

| S-EPMC3275063 | biostudies-literature

9a-Hy-droxy-3,8a-dimethyl-5-methyl-ene-4,4a,5,6,9,9a-hexa-hydro-naphtho-[2,3-b]furan-2(8aH)-one.

Project description:The title compound, C(15)H(18)O(3), was isolated from Lacta-rius piperatus (Fr.) S. F. Gary collected from the Kunming area in Yunnan province, China. The central cyclo-hexyl ring adopts a chair conformation, while the furan-one ring is close to planar (r.m.s. deviation = 0.0174 Å). The remaining methyl-ene cyclo-hexene ring has a flattened chair conformation. In the crystal, mol-ecules are linked via inter-molecular O-H⋯O and C-H⋯O hydrogen bonds into zigzag chains along the a axis.

| S-EPMC3051927 | biostudies-literature

3,3-Dimethyl-1,2,3,4,6,11-hexa-hydro-benzo[d]naphtho[2,3-b]furan-1,6,11-trione.

Project description:In the title compound, C(18)H(14)O(4), the cyclo-hexene ring adopts a sofa conformation. In the crystalline state, the mol-ecules are linked into a chain by weak inter-molecular C-H⋯O hydrogen bonds.

| S-EPMC2962159 | biostudies-literature

Crystal structure of 3a,6,6,9a-tetra-methyl-dodeca-hydro-naphtho-[2,1-b]furan-2-ol.

Project description:The title compound (common name: sclaral), C16H28O2, is a sclareolide derivative, which was synthesized from sclareolide itself. In the mol-ecule, the two six-membered rings, A and B, of the labdane skeleton adopt chair conformations and the five-membered O-containing heterocyclic ring C displays an envelope conformation, with the methine C atom of the fused C-C bond as the flap. In the crystal, mol-ecules are linked by O-H⋯O hydrogen bonds, forming chains propagating along [100].

| S-EPMC4647384 | biostudies-literature

6,8-Dihy-droxy-8a-methyl-3,5-dimethyl-idenedeca-hydro-naphtho-[2,3-b]furan-2(3H)-one.

Project description:The title compound, C(15)H(20)O(4), is a eudesmanolide isolated from the Chinese medicinal plant Carpesium tris-te Maxim. The mol-ecule contains three rings, viz. two fused six-membered rings in chair conformations and a five-membered ring in a flattened envelope conformation. In the crystal, two hy-droxy groups are involved in the formation of intra- and inter-molecular O-H?O hydrogen bonds. The H atoms in these groups are split, with site-occupation factors of 0.5. The inter-molecular hydrogen bonds link mol-ecules into chains propagating in [010].

| S-EPMC3515328 | biostudies-literature

3-Hydr-oxy-3a,6,8c-trimethyl-perhydro-oxireno[2',3':7,8]naphtho[1,2-b]furan-7(2H)-one.

Project description:The title compound, C(15)H(22)O(4), consists of two trans-fused six-membered rings and a trans-fused five-membered ?-lactone. The ep-oxy and hydroxyl groups are ?-oriented. The cyclo-hexane rings adopt half-chair and chair conformations and the lactone ring is in an envelope conformation. The mol-ecular structure is stabilized by one O-H?O and three C-H?O intra-molecular hydrogen bonds.

| S-EPMC2977239 | biostudies-literature

5,9-Dihy-droxy-9-methyl-3,6-dimethyl-ene-3a,4,5,6,6a,7,8,9,9a,9b-deca-hydro-azuleno[4,5-b]furan-2(3H)-one.

Project description:The title compound, C(15)H(20)O(4), was synthesized from 9?-hy-droxy-parthenolide (9?-hy-droxy-4,8-dimethyl-12-methyl-ene-3,14-dioxatricyclo-[9.3.0.0(2,4)]tetra-dec-7-en-13-one), which was isolated from the chloro-form extract of the aerial parts of Anvillea radiata. The seven-membered ring has a chair conformation, while the five-membered rings display twisted conformations. The dihedral angle between the seven-membered ring and the lactone ring is 21.69?(10)°. In the crystal, mol-ecules are linked into chains propagating along the c axis by inter-molecular O-H?O hydrogen bonds; an intra-molecular O-H?O link also occurs.

| S-EPMC3151879 | biostudies-literature

(2S,3'S,3a'R,5'R,7a'R)-5'-[(E)-5-(Furan-3-yl)-2-methyl-pent-1-en-1-yl]-3-hy-droxy-3',4,7'-trimethyl-1',2',3',3a',5',7a'-hexa-hydro-5H-spiro-[furan-2,4'-inden]-5-one.

Project description:The title compound, ircinianin, C25H32O4, belongs to the sesterterpene tetronic acid compound family and was isolated from the marine sponge Ircinia wistarii. These chemical scaffolds are pharmacologically relevant, since they represent a new class of glycine receptor modulators. The furan ring makes a dihedral angle of 35.14 (12)° to the 4-hy-droxy-3-methyl-furan-2(5H)-one ring. The crystal packing is characterized by inter-molecular O-H⋯O hydrogen bonds, which generate [010] chains.

| S-EPMC9462169 | biostudies-literature

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