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(S)-Ethyl 1,2,3,9-tetra-hydro-pyrrolo[2,1-b]quinazoline-1-carboxyl-ate.

ABSTRACT: The title chiral compound, C(14)H(16)N(2)O(2), was prepared by esterification of (S)-1,2,3,9-tetra-hydro-pyrrolo[2,1-b]quinazol-in-1-carboxylic acid in the presence of HCl/EtOH. In the mol-ecule, the quinazoline ring is non-planar and exhibits a distorted half-chair conformation, while the five-membered ring shows a typical envelope conformation. Inter-molecular C-H?N hydrogen bonding helps to stabilize the crystal structure.

SUBMITTER: Ma C

PROVIDER: S-EPMC2961280 | biostudies-literature | 2008 Apr

REPOSITORIES: biostudies-literature

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(S)-Ethyl 1,2,3,9-tetra-hydro-pyrrolo[2,1-b]quinazoline-1-carboxyl-ate.

Ma Chao C Du Gui-Jie GJ Tian Yu Y Sha Yu Y Cheng Mao-Sheng MS

Acta crystallographica. Section E, Structure reports online 20080410 Pt 5

The title chiral compound, C(14)H(16)N(2)O(2), was prepared by esterification of (S)-1,2,3,9-tetra-hydro-pyrrolo[2,1-b]quinazol-in-1-carboxylic acid in the presence of HCl/EtOH. In the mol-ecule, the quinazoline ring is non-planar and exhibits a distorted half-chair conformation, while the five-membered ring shows a typical envelope conformation. Inter-molecular C-H⋯N hydrogen bonding helps to stabilize the crystal structure. ...[more]

PMID: 21202305

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