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4-Chloro-3-fluoro-2-methyl-aniline-pyrrolidine-2,5-dione (1/1).

ABSTRACT: Chlorination of 3-fluoro-2-methyl-aniline with N-chloro-succinimide gave one major regioisomer whose structure was determined by X-ray crystallography. The product was found to have cocrystallized with succinimide, giving the title compound, C(7)H(7)ClFN·C(4)H(5)NO(2). The crystal structure is stabilized by N-H?O hydrogen-bonding and ?-? stacking inter-actions with a centroid-centroid distance of 3.4501?(8)?Å.

SUBMITTER: Mayes BA

PROVIDER: S-EPMC2961731 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature

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4-Chloro-3-fluoro-2-methyl-aniline-pyrrolidine-2,5-dione (1/1).

Mayes Benjamin A BA McGarry Patrick P Moussa Adel A Watkin David J DJ

Acta crystallographica. Section E, Structure reports online 20080628 Pt 7

Chlorination of 3-fluoro-2-methyl-aniline with N-chloro-succinimide gave one major regioisomer whose structure was determined by X-ray crystallography. The product was found to have cocrystallized with succinimide, giving the title compound, C(7)H(7)ClFN·C(4)H(5)NO(2). The crystal structure is stabilized by N-H⋯O hydrogen-bonding and π-π stacking inter-actions with a centroid-centroid distance of 3.4501 (8) Å. ...[more]

PMID: 21202974

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