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New advancements and developments in treatment of renal cell carcinoma: focus on pazopanib.

ABSTRACT: With the recent approval of pazopanib, an oral multitargeted tyrosine kinase inhibitor which potently targets vascular endothelial growth factor receptors 1-3, platelet-derived growth factor, and c-kit, six agents are now available for use in the management of metastatic renal cell carcinoma (RCC). Pazopanib has shown improved progression-free survival compared with placebo in treatment-naïve or cytokine-treated patients with metastatic RCC in large Phase II and Phase III clinical trials. Pazopanib has demonstrated a tolerable side effect profile and is currently being compared with sunitinib in a Phase III noninferiority trial. In this review, the outcomes of the clinical testing of pazopanib are discussed, as well as a perspective on the placement of pazopanib among other approved agents.

SUBMITTER: Cowey CL

PROVIDER: S-EPMC2962303 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature

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New advancements and developments in treatment of renal cell carcinoma: focus on pazopanib.

Cowey C Lance CL Sonpavde Guru G Hutson Thomas E TE

OncoTargets and therapy 20101005

With the recent approval of pazopanib, an oral multitargeted tyrosine kinase inhibitor which potently targets vascular endothelial growth factor receptors 1-3, platelet-derived growth factor, and c-kit, six agents are now available for use in the management of metastatic renal cell carcinoma (RCC). Pazopanib has shown improved progression-free survival compared with placebo in treatment-naïve or cytokine-treated patients with metastatic RCC in large Phase II and Phase III clinical trials. Pazopa ...[more]

PMID: 21049083

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