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Metabolome-proteome differentiation coupled to microbial divergence.

ABSTRACT: Tandem high-throughput proteomics and metabolomics were employed to functionally characterize natural microbial biofilm communities. Distinct molecular signatures exist for each analyzed sample. Deconvolution of the high-resolution molecular data demonstrates that identified proteins and detected metabolites exhibit organism-specific correlation patterns. These patterns are reflective of the functional differentiation of two bacterial species that share the same genus and that co-occur in the sampled microbial communities. Our analyses indicate that the two species have similar niche breadths and are not in strong competition with one another.

SUBMITTER: Wilmes P

PROVIDER: S-EPMC2962434 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature

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Metabolome-proteome differentiation coupled to microbial divergence.

Wilmes Paul P Bowen Benjamin P BP Thomas Brian C BC Mueller Ryan S RS Denef Vincent J VJ VerBerkmoes Nathan C NC Hettich Robert L RL Northen Trent R TR Banfield Jillian F JF

mBio 20101026 5

Tandem high-throughput proteomics and metabolomics were employed to functionally characterize natural microbial biofilm communities. Distinct molecular signatures exist for each analyzed sample. Deconvolution of the high-resolution molecular data demonstrates that identified proteins and detected metabolites exhibit organism-specific correlation patterns. These patterns are reflective of the functional differentiation of two bacterial species that share the same genus and that co-occur in the sa ...[more]

PMID: 20978538

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Metabolome-proteome differentiation coupled to microbial divergence.

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Metabolome-proteome differentiation coupled to microbial divergence.

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