Ontology highlight
ABSTRACT:
SUBMITTER: Olson CA
PROVIDER: S-EPMC2962918 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Olson C Anders CA Liao Hsiang-I HI Sun Ren R Roberts Richard W RW
ACS chemical biology 20080701 8
The complexity of the human proteome is greatly expanded by post-translational modifications. New tools capable of recognizing these modifications in a sequence-specific fashion provide a route to purify these modified proteins, to alter protein trafficking, and to visualize signal transduction in real time. Here, we have evolved novel, modification-specific ligands that target phosphorylated IkappaBalpha. To do this, we employed mRNA display-based in vitro selection using a 30-trillion-member p ...[more]