Ontology highlight
ABSTRACT:
SUBMITTER: Suddala KC
PROVIDER: S-EPMC6903423 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Suddala Krishna C KC Zhang Jinwei J
Nature structural & molecular biology 20191202 12
T-box riboswitches are modular bacterial noncoding RNAs that sense and regulate amino acid availability through direct interactions with tRNAs. Between the 5' anticodon-binding stem I domain and the 3' amino acid sensing domains of most T-boxes lies the stem II domain of unknown structure and function. Here, we report a 2.8-Å cocrystal structure of the Nocardia farcinica ileS T-box in complex with its cognate tRNA<sup>Ile</sup>. The structure reveals a perpendicularly arranged ultrashort stem I ...[more]