Ontology highlight
ABSTRACT:
SUBMITTER: Barnese K
PROVIDER: S-EPMC2962980 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Barnese Kevin K Sheng Yuewei Y Stich Troy A TA Gralla Edith B EB Britt R David RD Cabelli Diane E DE Valentine Joan Selverstone JS
Journal of the American Chemical Society 20100901 36
Manganese superoxide dismutase (MnSOD) from different species differs in its efficiency in removing high concentrations of superoxide (O(2)(-)), due to different levels of product inhibition. Human MnSOD exhibits a substantially higher level of product inhibition than the MnSODs from bacteria. In order to investigate the mechanism of product inhibition and whether it is a feature common to eukaryotic MnSODs, we purified MnSOD from Saccharomyces cerevisiae (ScMnSOD). It was a tetramer with 0.6 eq ...[more]