Dataset Information
Association between higher serum fetuin-A concentrations and abnormal albuminuria in middle-aged and elderly chinese with normal glucose tolerance.
Ontology highlight
ABSTRACT: Objective
To study the association of serum fetuin-A as a potential risk factor with abnormal albuminuria in Chinese individuals with normal glucose tolerance (NGT).Research design and methods
The cross-sectional analysis included 607 men and 1,042 women aged 40 or older with NGT.Results
Women with combined microalbuminuria and macroalbuminuria (n=68) had significantly higher serum fetuin-A concentrations than those with normal albumin excretion (n=974) (314.3 vs. 280.4 mg/l, P=0.007). Compared with the lowest quartile, the highest quartile of serum fetuin-A had 40% increased risk of abnormal albuminuria after the multiple adjustments in women (Pfor trend=0.02). However, the associations were not detected in men.Conclusions
Higher serum fetuin-A was associated with abnormal albuminuria independent of BMI, waist circumference, homeostasis model assessment of insulin resistance, blood pressure, and other determinants of albuminuria in middle-aged and elderly Chinese women with NGT.
SUBMITTER: Li M
PROVIDER: S-EPMC2963513 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Publications
Association between higher serum fetuin-A concentrations and abnormal albuminuria in middle-aged and elderly chinese with normal glucose tolerance.
Diabetes care 20100816 11
<h4>Objective</h4>To study the association of serum fetuin-A as a potential risk factor with abnormal albuminuria in Chinese individuals with normal glucose tolerance (NGT).<h4>Research design and methods</h4>The cross-sectional analysis included 607 men and 1,042 women aged 40 or older with NGT.<h4>Results</h4>Women with combined microalbuminuria and macroalbuminuria (n=68) had significantly higher serum fetuin-A concentrations than those with normal albumin excretion (n=974) (314.3 vs. 280.4 m ...[more]