Albuminuria, Cerebrovascular Disease and Cortical Atrophy: among Cognitively Normal Elderly Individuals.
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ABSTRACT:
SUBMITTER: Cho EB
PROVIDER: S-EPMC4754729 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Publications
Albuminuria, Cerebrovascular Disease and Cortical Atrophy: among Cognitively Normal Elderly Individuals.
Cho Eun Bin EB Shin Hee-Young HY Park Sang Eon SE Chun Phillip P Jang Hye Ryoun HR Yang Jin-ju JJ Kim Hee Jin HJ Kim Yeo Jin YJ Jung Na-Yeon NY Lee Jin San JS Lee Juyoun J Jang Young Kyoung YK Jang Eun Young EY Kang Mira M Lee Jong-Min JM Kim Changsoo C Min Ju-Hong JH Ryu Seungho S Na Duk L DL Seo Sang Won SW
Scientific reports 20160215
We tested the hypothesis that decreased glomerular filtration rate and albuminuria have different roles in brain structure alterations. We enrolled 1,215 cognitively normal individuals, all of whom underwent high-resolution T1-weighted volumetric magnetic resonance imaging scans. The cerebral small vessel disease burdens were assessed with white matter hyperintensities (WMH), lacunes, and microbleeds. Subjects were considered to have an abnormally elevated urine albumin creatinine ratio if the v ...[more]
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