Ontology highlight
ABSTRACT:
SUBMITTER: Lin D
PROVIDER: S-EPMC2963612 | biostudies-literature | 2010
REPOSITORIES: biostudies-literature
Lin Dandan D Liu Chunliang C Xue Mengxing M Liu Rengyun R Jiang Lan L Yu Xiao X Bao Guangming G Deng Fang F Yu Mingjie M Ao Jiafu J Zhou Yifeng Y Wu Depei D Liu Haiyan H
PloS one 20101025 10
<h4>Background</h4>Interleukin-15 (IL-15) plays important roles in the immune system and in the development of hematopoietic cells. Previous studies revealed that five SNPs in IL-15, rs10519612, rs10519613, rs35964658, rs17007695 and rs17015014, were significantly associated with childhood Acute Lymphoblastic Leukemia (ALL) treatment response. In adult ALL, the expression of IL-15 was also correlated with the immunophenotypes of ALL. Therefore, we hypothesize that SNPs of IL-15 might also be ass ...[more]