Ontology highlight
ABSTRACT:
SUBMITTER: Guiducci C
PROVIDER: S-EPMC2964153 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Guiducci Cristiana C Gong Mei M Xu Zhaohui Z Gill Michelle M Chaussabel Damien D Meeker Thea T Chan Jean H JH Wright Tracey T Punaro Marilynn M Bolland Silvia S Soumelis Vassili V Banchereau Jacques J Coffman Robert L RL Pascual Virginia V Barrat Franck J FJ
Nature 20100601 7300
Glucocorticoids are widely used to treat patients with autoimmune diseases such as systemic lupus erythematosus (SLE). However, regimens used to treat many such conditions cannot maintain disease control in the majority of SLE patients and more aggressive approaches such as high-dose methylprednisolone pulse therapy are used to provide transient reductions in disease activity. The primary anti-inflammatory mechanism of glucocorticoids is thought to be NF-kappaB inhibition. Recognition of self nu ...[more]