Ontology highlight
ABSTRACT:
SUBMITTER: Field J
PROVIDER: S-EPMC2964313 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Field Judith J Browning Sharon R SR Johnson Laura J LJ Danoy Patrick P Varney Michael D MD Tait Brian D BD Gandhi Kaushal S KS Charlesworth Jac C JC Heard Robert N RN Stewart Graeme J GJ Kilpatrick Trevor J TJ Foote Simon J SJ Bahlo Melanie M Butzkueven Helmut H Wiley James J Booth David R DR Taylor Bruce V BV Brown Matthew A MA Rubio Justin P JP Stankovich Jim J
PloS one 20101026 10
We conducted an association study across the human leukocyte antigen (HLA) complex to identify loci associated with multiple sclerosis (MS). Comparing 1927 SNPs in 1618 MS cases and 3413 controls of European ancestry, we identified seven SNPs that were independently associated with MS conditional on the others (each P ≤ 4 x 10(-6)). All associations were significant in an independent replication cohort of 2212 cases and 2251 controls (P ≤ 0.001) and were highly significant in the combined datase ...[more]