CD6 gene polymorphism rs17824933 is associated with multiple sclerosis in Indian population.

ABSTRACT:

Background

Multiple sclerosis (MS) prevalence has increased worldwide. The known genetic association for MS in the west has not been studied in detail in nonwhite populations and particularly Indians.

Objective

The objective of this study was to evaluate some known genetic variations outside the major histocompatibility complex (MHC) region associated with MS in patients of Indian origin.

Materials and methods

We investigated 10 gene-associated single nucleotide polymorphisms (SNP's) outside the MHC region in 300 patients and 720 unrelated controls. Genotyping was performed on an ABI7500 real-time polymerase chain reaction genotyping platform using predesigned TaqMan SNP genotyping assays.

Results

CD6 gene associated SNP (rs17824933) showed significant association with MS (P = 4.2 × 10^-5, odds ratio [OR] = 2.24, confidence interval (CI) = 1.51-3.33). A modest association was also noted for TMEM39A rs1132200 (P = 0.023, OR = 1.41, CI = 1.05-1.91) and IL2RA rs2104286 (P = 0.04, OR = 1.3, CI = 1.006-1.67). In the remaining SNPs, the allele frequencies were overexpressed in patients when compared to healthy controls.

Conclusion

Our data illustrate the similarity in risk association between Indian and European populations for MS.

SUBMITTER: D'Cunha MA 

PROVIDER: S-EPMC5144471 | biostudies-literature | 2016 Oct-Dec

REPOSITORIES: biostudies-literature