Unknown

Dataset Information

0

Spatial relation between microbleeds and amyloid deposits in amyloid angiopathy.


ABSTRACT: Advanced cerebrovascular ?-amyloid deposition (cerebral amyloid angiopathy, CAA) is associated with cerebral microbleeds, but the precise relationship between CAA burden and microbleeds is undefined. We used T2*-weighted magnetic resonance imaging (MRI) and noninvasive amyloid imaging with Pittsburgh Compound B (PiB) to analyze the spatial relationship between CAA and microbleeds. On coregistered positron emission tomography (PET) and MRI images, PiB retention was increased at microbleed sites compared to simulated control lesions (p = 0.002) and declined with increasing distance from the microbleed (p < 0.0001). These findings indicate that microbleeds occur preferentially in local regions of concentrated amyloid and support therapeutic strategies aimed at reducing vascular amyloid deposition.

SUBMITTER: Dierksen GA 

PROVIDER: S-EPMC2964411 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature

altmetric image

Publications


Advanced cerebrovascular β-amyloid deposition (cerebral amyloid angiopathy, CAA) is associated with cerebral microbleeds, but the precise relationship between CAA burden and microbleeds is undefined. We used T2*-weighted magnetic resonance imaging (MRI) and noninvasive amyloid imaging with Pittsburgh Compound B (PiB) to analyze the spatial relationship between CAA and microbleeds. On coregistered positron emission tomography (PET) and MRI images, PiB retention was increased at microbleed sites c  ...[more]

Similar Datasets

| S-EPMC7674181 | biostudies-literature
| S-EPMC4814270 | biostudies-literature
| S-EPMC7322009 | biostudies-literature
| S-EPMC4937037 | biostudies-literature
| S-EPMC6483878 | biostudies-literature
| S-EPMC4325636 | biostudies-literature
| S-EPMC4827375 | biostudies-literature
| S-EPMC7309570 | biostudies-literature
| S-EPMC5904220 | biostudies-literature
| S-EPMC5541242 | biostudies-other