Ontology highlight
ABSTRACT:
SUBMITTER: Keable A
PROVIDER: S-EPMC4827375 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Keable Abby A Fenna Kate K Yuen Ho Ming HM Johnston David A DA Smyth Neil R NR Smith Colin C Al-Shahi Salman Rustam R Samarasekera Neshika N Nicoll James A R JA Attems Johannes J Kalaria Rajesh N RN Weller Roy O RO Carare Roxana O RO
Biochimica et biophysica acta 20150829 5
Deposition of amyloid β (Aβ) in the walls of cerebral arteries as cerebral amyloid angiopathy (CAA) suggests an age-related failure of perivascular drainage of soluble Aβ from the brain. As CAA is associated with Alzheimer's disease and with intracerebral haemorrhage, the present study determines the unique sequence of changes that occur as Aβ accumulates in artery walls. Paraffin sections of post-mortem human occipital cortex were immunostained for collagen IV, fibronectin, nidogen 2, Aβ and sm ...[more]