Ontology highlight
ABSTRACT:
SUBMITTER: Kyro K
PROVIDER: S-EPMC2965201 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Kyro Kelly K Manandhar Surya P SP Mullen Daniel D Schmidt Walter K WK Distefano Mark D MD
Bioorganic & medicinal chemistry 20100612 15
Isoprenylation is a post-translational modification that increases protein hydrophobicity and helps target certain proteins to membranes. Ras converting enzyme 1 (Rce1p) is an endoprotease that catalyzes the removal of a three residue fragment from the C-terminus of isoprenylated proteins. To obtain structural information about this membrane protein, photoaffinity labeling agents are being prepared and employed. Here, we describe the synthesis of a benzophenone-containing peptide substrate analo ...[more]