Ontology highlight
ABSTRACT:
SUBMITTER: Wu Y
PROVIDER: S-EPMC4862033 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Wu Yuteng Y Olsen Lasse B LB Lau Yu Heng YH Jensen Claus Hatt CH Rossmann Maxim M Baker Ysobel R YR Sore Hannah F HF Collins Súil S Spring David R DR
Chembiochem : a European journal of chemical biology 20160316 8
Photoaffinity labelling is a useful method for studying how proteins interact with ligands and biomolecules, and can help identify and characterise new targets for the development of new therapeutics. We present the design and synthesis of a novel multifunctional benzophenone linker that serves as both a photo-crosslinking motif and a peptide stapling reagent. Using double-click stapling, we attached the benzophenone to the peptide via the staple linker, rather than by modifying the peptide sequ ...[more]