Ontology highlight
ABSTRACT:
SUBMITTER: Eichert A
PROVIDER: S-EPMC2965234 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Eichert André A Behling Katja K Betzel Christian C Erdmann Volker A VA Fürste Jens P JP Förster Charlotte C
Nucleic acids research 20100608 19
'Locked nucleic acids' (LNAs) are known to introduce enhanced bio- and thermostability into natural nucleic acids rendering them powerful tools for diagnostic and therapeutic applications. We present the 1.9 Å X-ray structure of an 'all LNA' duplex containing exclusively modified β-D-2'-O-4'C-methylene ribofuranose nucleotides. The helix illustrates a new type of nucleic acid geometry that contributes to the understanding of the enhanced thermostability of LNA duplexes. A notable decrease of sev ...[more]