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What lessons can be learned from studying the folding of homologous proteins?

ABSTRACT: The studies of the folding of structurally related proteins have proved to be a very important tool for investigating protein folding. Here we review some of the insights that have been gained from such studies. Our highlighted studies show just how such an investigation should be designed and emphasise the importance of the synergy between experiment and theory. We also stress the importance of choosing the right system carefully, exploiting the excellent structural and sequence databases at our disposal.

SUBMITTER: Nickson AA

PROVIDER: S-EPMC2965948 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature

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What lessons can be learned from studying the folding of homologous proteins?

Nickson Adrian A AA Clarke Jane J

Methods (San Diego, Calif.) 20100604 1

The studies of the folding of structurally related proteins have proved to be a very important tool for investigating protein folding. Here we review some of the insights that have been gained from such studies. Our highlighted studies show just how such an investigation should be designed and emphasise the importance of the synergy between experiment and theory. We also stress the importance of choosing the right system carefully, exploiting the excellent structural and sequence databases at ou ...[more]

PMID: 20570731

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