Ontology highlight
ABSTRACT:
SUBMITTER: Batey S
PROVIDER: S-EPMC2645590 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Batey Sarah S Nickson Adrian A AA Clarke Jane J
HFSP journal 20081015 6
There have been relatively few detailed comprehensive studies of the folding of protein domains (or modules) in the context of their natural covalently linked neighbors. This is despite the fact that a significant proportion of the proteome consists of multidomain proteins. In this review we highlight some key experimental investigations of the folding of multidomain proteins to draw attention to the difficulties that can arise in analyzing such systems. The evidence suggests that interdomain in ...[more]