Ontology highlight
ABSTRACT:
SUBMITTER: Wang J
PROVIDER: S-EPMC2966505 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Neurobiology of aging 20100701 12
Oligomeric β-amyloid (Aβ) has recently been linked to synaptic plasticity deficits, which play a major role in progressive cognitive decline in Alzheimer's disease (AD). Here we present evidence that chronic oral administration of carvedilol, a nonselective β-adrenergic receptor blocker, significantly attenuates brain oligomeric β-amyloid content and cognitive deterioration in 2 independent AD mouse models. We found that carvedilol treatment significantly improved neuronal transmission, and that ...[more]