Ontology highlight
ABSTRACT:
SUBMITTER: Park SY
PROVIDER: S-EPMC2967377 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Park Sun-Yang SY Cromie Michael J MJ Lee Eun-Jin EJ Groisman Eduardo A EA
Cell 20100901 5
Bacterial mRNAs often contain leader sequences that respond to specific metabolites or ions by altering expression of the associated downstream protein-coding sequences. Here we report that the leader RNA of the Mg(2+) transporter gene mgtA of Salmonella enterica, which was previously known to function as a Mg(2+)-sensing riboswitch, harbors an 18 codon proline-rich open reading frame-termed mgtL-that permits intracellular proline to regulate mgtA expression. Interfering with mgtL translation by ...[more]